Evaluation of Microcirculation With Photoplethysmography (Pulse Oximetry) in Healthy Volunteers and Ventilated Patients
- Conditions
- MicrocirculationPhotoplethysmography
- Interventions
- Other: photoplethysmography
- Registration Number
- NCT06141681
- Lead Sponsor
- Hospital Privado de Comunidad de Mar del Plata
- Brief Summary
The objective of this observational study is to explore microcirculation in healthy volunteers and in ventilated patients in the operating room and in critical care.
The general objective of this study is to evaluate microcirculation with photoplethysmography (PPG) in different pathophysiological situations and to compare PPG with available standard methods. Specifically, evaluate the correlation between the determinations of AC-DC waves obtained by Photoplethysmography (PPG) and those obtained in different dynamic tests in healthy volunteers.
To compare microcirculation assessments \[capillary refill time (CRT), perfusion index (PI), perfusion index variability (PIV)\] with measurements obtained by PPG in the context of critically ill patients.
To compare microcirculation assessments (CRT, PI PVI) with measurements obtained by PPG in the context of patients on invasive mechanical ventilation (IMV) in the operating room and in critical care.
- Detailed Description
An attempt is made to explore different physiological aspects that affect microcirculation such as vascular tone and blood volume.
Photoplethysmography usually examines the AC wave equivalent to the pulsatile wave, however the DC component has been less explored and can account for the microcirculation and volemia status of the subjects.
Since there is no gold standard, it will be compared against different validated methods.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Written informed consent.
- Age > 18 years.
- Pregnancy.
- Smokers.
- Respiratory and/or cardiovascular pathologies.
- Peripheral vascular disease.
Operation room or Critical care Unit patients
Inclusion criteria:
- Written informed consent.
- Age > 18 years.
- Critical patients ventilated in the ICU of any origin.
Exclusion criteria:
- Known peripheral vascular disease.
- Burns on both upper limbs.
- Trauma to both upper limbs.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy volunteers photoplethysmography \>18 years old healthy Patients with ventilatory support in the operating room or critical care unit photoplethysmography patient in the ICU or operating room with a requirement for hemodynamic monitoring and ventilatory support Patients in critical care unit photoplethysmography patient in ICU with requirement for hemodynamic monitoring
- Primary Outcome Measures
Name Time Method variations in AC signal of photoplethysmography Through study completion, an average of 1 year Changes in the AC wave of photoplethysmography (it does not currently have standardized measurement units) will be evaluated in each functional test (CRT, LPR, venous occlusion test, progressive arterial occlusion test). It will be treated as a continuous numerical variable.
variations in DC signal of photoplethysmography Through study completion, an average of 1 year Changes in the DC wave of photoplethysmography (it does not currently have standardized measurement units) will be evaluated in each functional test (CRT, LPR, venous occlusion test, progressive arterial occlusion test). It will be treated as a continuous numerical variable.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital Privado de Comunidad
🇦🇷Mar Del Plata, Buenos Aires, Argentina