Manfort: testing a dietary supplement for improving semen quality in patients with low or no sperm count
Not Applicable
Completed
- Conditions
- Semen quality improvement of patients with azoospermia and low sperm countUrological and Genital DiseasesMale infertility
- Registration Number
- ISRCTN15796121
- Lead Sponsor
- Egypt Innovate for Development and Training Foundation
- Brief Summary
2019 Results article in https://dx.doi.org/10.18203/2320-1770.ijrcog20196047 (added 16/02/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 33
Inclusion Criteria
1. Aged 36 to 46 years
2. Married
3. Low sperm total count: sperm concentration ?17 million after two semen analysis tests
4. Azoospermia patients show spermatogonia cells in each semen analysis
5. Body weight ranging from 65 to 95 kg
6. All patients living in a geographic area where follow-up can be accomplished
Exclusion Criteria
1. Patients suffering from other diseases such as varicocele were exempted from this study
2. Patients characterized with Sertoli cell only syndrome or absence of spermatogonia
3. Patients who take medications are exempted from this study to prevent semen analysis disturbance
4. Signs of infection or fever
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Measured at baseline (pre-treatment) and 4 months (post-treatment) from two semen specimens collected by masturbation:<br> 1. Semen volume (by weight [g])<br> 2. Sperm concentration (hemacytometer)<br> 3. Sperm motility (phase-contrast microscope)<br> 4. Semen WBCs (high power field (HPF) using the hemacytometer slide and light microscope)<br>
- Secondary Outcome Measures
Name Time Method 1. Liver function measured using spectrophotometric assay of alanine transaminase (ALT) and aspartate aminotransferase (AST)