NCT03610035已完成1 期
A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of NPT189 in Healthy Subjects
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Safety of a single intravenous (IV) infusion of NPT189 (subjects experiencing adverse events)
研究概览
简要总结
The purpose of the study is to evaluate the safety and tolerability of single dose of NPT189 in healthy volunteers. The study will also evaluate the pharmacokinetic characteristics of NPT189.
详细描述
This study is a Phase1, randomized, double-blind, placebo-controlled, single dose, dose escalation safety and tolerability study of NPT189 in health subjects. Six dose cohorts are planned each with a maximum of 8 participants per cohort. Participants will receive NPT189 by intravenous (IV) or a matching placebo by intravenous infusion. Safety, tolerability, and pharmacokinetics will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female subjects between the ages of 18 and 65 years (inclusive);
- •Has provided written informed consent to participate in the study;
- •Weigh ≥ 45kg and ≤ 120kg with Body Mass Index of 18-32 inclusive;
- •Subject Rescreening: This study does not permit the re-enrollment of a subject who has discontinued from the study as a pre-treatment failure without approval from the sponsor unless the reason they were not included was because the required number of subjects needed at the time of randomization had already been met. Rescreened subjects must continue to meet all inclusion and exclusion criteria. All screening procedures must be performed within 28 days of dose administration
- •Female subjects of childbearing potential (defined as not surgically sterile or at least two years postmenopausal confirmed by a Screening Follicle Stimulating Hormone (FSH) level of > 40) must agree to use one of the following forms of contraception from 60 days prior through 90 days following the dose of Study Drug: hormonal (oral, transdermal, implant, or injection), barrier (condom, diaphragm with spermicide), intrauterine device (IUD), complete abstinence, or vasectomized partner (6 months minimum) or male subjects who are sexually active with women of child-bearing potential must agree to complete abstinence or to use a condom for 90 days following the dose of Study Drug;
- •No clinically significant abnormal findings on physical examination, vital signs, ECG, or clinical laboratory evaluation during screening; and systolic blood pressure between 140 mm and 90 mm Hg and diastolic blood pressure between 90 mm and 45 mm Hg.
- •Can understand and sign the informed consent document, can communicate with the investigator, and can understand and comply with the requirements of the protocol.
排除标准
- •Have a past or present serious medical illness or other medical or social reason that in the opinion of the Principal Investigator, would jeopardize the safety of the subject or impact the validity of the study results;
- •Participation in a clinical trial (other than a screening visit) within 60 days of study drug administration;
- •Use of any over-the-counter or prescription medication within 14 days prior to the dose of Study Drug or during the study, with the exception of hormonal contraceptives for women of childbearing potential, unless approved by the Principal Investigator or use of beta-blockers within 30 days prior to dose of Study Drug or during the study;
- •Donation of blood or plasma within 30 days of the dose of Study Drug and throughout the duration of the study and for male subjects, donation of sperm through the duration of the study;
- •Women who are nursing, pregnant, suspected of being pregnant, or trying to become pregnant, or are lactating, have a positive serum pregnancy test at screening or urine pregnancy test prior to administration of Study Drug regardless of childbearing potential;
- •Positive blood screen for HIV, hepatitis B surface antigen (HbSAg), or hepatitis C as Screening, or a positive urine screen for alcohol (Day -1 only) or, drugs of abuse, or cotinine at Screening and on Day -1;
- •Have clinically significant abnormalities in laboratory values as judged by the clinical investigator;
- •Have a history of alcoholism and/or drug abuse;
研究组 & 干预措施
Experimental
Experimental
NPT189
干预措施: NPT189 (Drug)
Placebo Comparator
Placebo Comparator
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Safety of a single intravenous (IV) infusion of NPT189 (subjects experiencing adverse events)
时间窗: Day 1 through to Day 49
Summary of the frequency and percentage of
次要结局
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189 (Cmax)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189 (Tmax)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189 (AUClast)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189 (AUCinf)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189. Terminal elimination half-life (t 1/2)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189. Clearance (CL)(Day 1 through to Day 49)
- Profile of pharmacokinetics (PK) of a single intravenous (IV) infusion of NPT189. Volume of distribution (Vd)(Day 1 through to Day 49)
研究者
研究点 (1)
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