Oral Glucose Stimulation in Normal-weight and Obese Volunteers
Not Applicable
Completed
- Conditions
- Endocrine System Diseases
- Registration Number
- NCT01875575
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of > 30
- Normal eating habits
- Age 18-40 years
- Stable body weight for at least three months
Exclusion Criteria
- Smoking
- Substance abuse
- Regular intake of medications (except for oral contraceptives)
- Medical or psychiatric illness
- Any abnormality detected during the screening procedure
- history of gastrointestinal disorders
- food allergies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Effect of different oral glucose loads on secretion of satiation hormones 240min. Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured
- Secondary Outcome Measures
Name Time Method Effect of different oral glucose loads on gastric emptying 240min. measured by C13 breath test
Trial Locations
- Locations (1)
University Hospital Basel
🇨🇭Basel, Switzerland
University Hospital Basel🇨🇭Basel, Switzerland