Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

Phase 1

Completed

• Conditions: Endocrine System Diseases

• Registration Number: NCT02020395
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.

Detailed Description

The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.

Study Timeline

• Study Start: 2009-06
• Primary Completion: 2009-12
• Study Completion: 2013-10
• Status Verified: 2013-12
• Study First Submitted: 2013-12-12
• Study First Submitted QC: 2013-12-18
• Last Update Submitted: 2013-12-18
• Study First Posted: 2013-12-24
• Last Update Posted: 2013-12-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• caucasian youth
• pubertal Tanner stage x, y, or z

Exclusion Criteria

• fasting plasma glucose > 7.0 mmol/L
• significant illness
• taking medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents	2 hours blood sampling	Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents

Secondary Outcome Measures

Name	Time	Method
Association between gastrointestinal peptides and insulin release	2 hours blood sampling	Dynamics of gastrointestinal peptide secretion including Tmax and Cmax

Trial Locations

Locations (1)

University Hospital Basel, Division of Gastroenterology and Hepatology; 🇨🇭 Basel, Switzerland