Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease
- Conditions
- Pulmonary Hypertension
- Interventions
- Other: 3-Helium gas
- Registration Number
- NCT02026531
- Brief Summary
The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9
- All cases referred to the clinic for assessment for possible pulmonary hypertension.
- patients with a cardiac pacemaker or retained temporary pacing wire
- patients with aneurysm clip
- non MRI compatible heart valve prosthesis
- intra orbital metalic foreign body
- pregnancy
- metal prosthesis/spinal rods
- retained shrapnel
- cochlear implants/bladder stimulator
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 3-Helium inhalation gas 3-Helium gas This is a pilot study. The aim is to recruit 20 patients who will all receive the product under investigation.
- Primary Outcome Measures
Name Time Method pulmonary artery diameter (mm) up to 3 months Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital
🇬🇧Sheffield, South Yorkshire, United Kingdom