Timing of Endoscopy for Acute Variceal Bleeding in Patients With Cirrhosis (CHESS1905): a Nationwide Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,300
- 试验地点
- 1
- 主要终点
- the incidence of 5-day rebleeding after emergency endoscopy
研究概览
简要总结
Cirrhotic patients with AVB across 34 university medical centers in 30 cities in China from February 2013 to May 2020 who underwent endoscopy within 24 hours were included in this study. Patients were divided into an urgent endoscopy group (endoscopy <6h after admission) and an early endoscopy group (endoscopy 6-24h after admission). Outcomes included the incidence of 5-day rebleeding, in-hospital mortality, need for intensive care unit (ICU) and the length of hospital stay after the endoscopy management. Multivariable analysis was performed to identify risk factors for rebleeding. A propensity score matching (PSM) analysis was performed to achieve a balance at baseline between the urgent and early groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •established diagnosis of cirrhosis (based on liver biopsy or the combination of clinical, biochemical, and imaging findings)
- •witnessed or reported evidence of gastrointestinal haemorrhage (hematemesis, melenemesis, or hematochezia)
- •esophageal or gastric varices confirmed endoscopically as the source of bleeding
排除标准
- •severe dysfunction of a major extrahepatic organ (e.g., heart failure, pulmonary disease, and terminal malignancy except hepatocellular carcinoma)
- •history of endoscopic therapy for varices (ligation or sclerotherapy) within three months
- •incomplete or missing data
结局指标
主要结局
the incidence of 5-day rebleeding after emergency endoscopy
时间窗: 6 months
次要结局
- need for ICU(6 months)
- the length of hospital stay(6 months)
- the in-hospital mortality(6 months)
研究者
Xiaolong Qi
Chief, Institute of Portal Hypertension, The First Hospital of Lanzhou University
Hepatopancreatobiliary Surgery Institute of Gansu Province