ANalyzing Olfactory Dysfunction Mechanisms In COVID-19
- Conditions
- SARS-CoV-2
- Interventions
- Other: Sampling of tissue
- Registration Number
- NCT04445597
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
We aim to understand the mechanism of olfactory dysfunction in COVID-19.
- Detailed Description
In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization.
By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders.
In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
- Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively
- none
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description COVID-19 positive or negative patients Sampling of tissue Hospitalised patients with or without COVID-19 (with or without olfactory dysfunctions)
- Primary Outcome Measures
Name Time Method Prevalence of SARS-CoV-2 in the sampled tissue Immediately after death In the sampled tissues, the investigators will determine presence of SARS-CoV-2 by means of immunohistochemistry, RNA-scope and spatial transcriptomics
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UZ Leuven
🇧🇪Leuven, Vlaams-Brabant, Belgium