High Intensity Training in Patients With Spinal and Bulbar Muscular Atrophy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spinal and Bulbar Muscular Atrophy
- Sponsor
- Karen Brorup Heje Pedersen
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Incremental test
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
We want investigate if high intensity training can increase daily functionality without causing muscle damage in patients Spinal and Bulbar Muscular Atrophy . We want to study if there is a difference in effect with supervised and unsupervised training. Furthermore we want to study if a supervised training program will motivate participants to continue training by the end of the program.
Investigators
Karen Brorup Heje Pedersen
Bachelor in medicine
Rigshospitalet, Denmark
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with Spinal and bulbar muscular atrophy or
- •Healthy control subjects matched individually with participating patients on age, sex, BMI and activity level.
Exclusion Criteria
- •More than 1 hour of fitness weekly before inclusion
- •Other disease possibly confounding the results
- •Pregnancy or breastfeeding
- •Participations in other scientific studies wich could influence on the results during the last 30 days before inclusion.
- •Physical and/or mental conditions preventing participating in the study protocol.
Outcomes
Primary Outcomes
Incremental test
Time Frame: Baseline, week 6, week 11, week 18
Primary outcome is changes from baseline in maximal oxygen consumption and maximal workload after a 8 week supervised training program followed by a 8 week non-supervised optional training period. during and after 8 weeks of High Intensity Training on a cycle ergometer. The outcome is measured by an incremental test on a cycle ergometer.
Secondary Outcomes
- Functional test(Baseline, week 6, week 11, week 18.)
- Self-rated muscle fatigue, muscle pain and activity level(Every day in week 1-11)
- Serum concentrations of Creatine Kinase (CK)(Baseline, Week 3,4,5,6,7,8,9,10,11, week 18.)
- Activity level(Baseline, week 10 and week 18.)