Rehabilitation in MS: Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Bert Op't Eijnde
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- insulin sensitivity (insulin profile)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients.
It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
Investigators
Bert Op't Eijnde
Ph.D
Hasselt University
Eligibility Criteria
Inclusion Criteria
- •Diagnosed MS according to the McDonald criteria
- •Expanded Disability Status Scale (EDSS) between 0.5 and 6
- •Be able to train 5 times in 2 weeks at the University
Exclusion Criteria
- •Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2)
- •Having had an relapse in a period of 3 months prior to the start of the intervention period
- •Having an relapse during the intervention period
- •Pregnancy and other contra indications for physical activity
- •Mental disorders
Outcomes
Primary Outcomes
insulin sensitivity (insulin profile)
Time Frame: change from baseline to 12 weeks
glucose and insulin concentration measurements in blood
muscle contractile properties
Time Frame: from baseline to 12 weeks
measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ...
Secondary Outcomes
- muscle strength of knee extensor/flexor(change from baseline to 12 weeks)
- body composition(Change from baseline to 12 weeks)
- aerobic capacity(change from baseline to 12 weeks)
- cytokine profile(change from baseline to 12 weeks)
- Self-reported measures(Change from baseline to 12 weeks)