Effect of High Intensity Interval Training in Patients With Multiple Sclerosis

Not Applicable

Recruiting

• Conditions: Multiple Sclerosis
• Interventions: Other: high intensity interval training

• Registration Number: NCT05954195
• Lead Sponsor: Cairo University

Brief Summary

In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength. This could help guide the development of standardized clinical guidelines and direct clinical decision making by the physical therapists whether to implement this type of exercises or not.

Detailed Description

Multiple sclerosis patients have considerably negative effects on the community and the national and international economy. Chronic symptoms of MS such as fatigue, cognitive impairments, emotional burden and diminished physical functioning considerably affect the daily lives of people with MS and may interfere with social and quality of life factors as friendships, family relationships and occupational status. HIIT has induced significant improvements in physiological conditioning in healthy and clinical populations, and might be appropriate for persons with MS. Recently, several RCTs have been published evaluating the effect of HIIT on MS patients. Consequently, this study will systematically review all these recent literature to direct the physiotherapists whether to implement this type of exercises or not.

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-12
• Study First Submitted QC: 2023-07-12
• Last Update Submitted: 2023-07-12
• Study Start: 2023-07-20
• Study First Posted: 2023-07-20
• Last Update Posted: 2023-07-20
• Primary Completion: 2023-11-30
• Study Completion: 2023-12-18

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Studies: English full texts of RCTs only, Participants: multiple sclerosis patients with age from (20-50) years old irrespectively of sex, subtype of MS, race, diagnostic criteria, community or onset of the disease, Intervention: HIIT, any comparator.

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Exclusion Criteria

• Studies other than English full text RCTs, non adults younger than 20 years and older than 50 years, populations other than multiple sclerosis.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HIIT group	high intensity interval training	The group who received high intensity interval training
control/comparator group	high intensity interval training	control group that might be placebo group, standard care group or no intervention group

Primary Outcome Measures

Name	Time	Method
cognitive function	8-12 weeks or less	serum levels of serotonin and brain derived necrotic factor (BDNF)

Secondary Outcome Measures

Name	Time	Method
mental processing speed	8-12 weeks or less	symbol digit modalities test

Trial Locations

Locations (1)

Azzarqa; 🇪🇬 Damietta, Egypt