Central Hemodynamics, Augmentation index and Microcirculation after Phlebotomy
- Conditions
- Heamochroomatosis (Iron overlad)polycythemia (too much red blood cels)1003815810019654
- Registration Number
- NL-OMON38739
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Without volume replacement:
- Patients aged 18-75 years receiving phlebotomy at regular intervals (for example because of hemochromatosis, porphyria and polycythemia vera)
- Known to tolerate phlebotomy
- Willing to participate
- Able to provide informed consent.
Patients which are known to tolerate phlebotomy without any adverse events are included in the *no-volume replacement group.* Patients who have experienced adverse events after phlebotomy in the past, and are previously assigned to receive volume replacement by their attending physician, are included in the *volume replacement group.* We aim to include the same amount of patients in each group.
- Pacemaker or ICD device
- Atrial fibrillation
- Mechanical heart valve
- Congestive heart failure (*NYHA III/IV)
- Unable to stand up
- Uncontrolled hypertension (BP>180/110 mmHg)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Significant difference in aortic augmentation as well as difference in<br /><br>central BP of * 10 mmHg systolic or * 5 mmHg diastolic before and after<br /><br>phlebotomy in supine and standing position with or without counter maneuvers.-<br /><br>- Difference in aortic augmentation of * 4% as well as difference in central BP<br /><br>of * 10 mmHg systolic or * 5 mmHg diastolic after phlebotomy in patients with<br /><br>or without saline infusion (viscosity changed/unchanged). </p><br>
- Secondary Outcome Measures
Name Time Method <p>To assess the effects of phlebotomy on cardiac output and peripheral resistance<br /><br>while supine and after standing<br /><br>To assess the effects of phlebotomy on forward and backward waves in supine<br /><br>position and after standing<br /><br>To assess the effects of phlebotomy with saline repletion on cardiac output and<br /><br>peripheral resistance while supine and after standing<br /><br>To assess the effects of phlebotomy with saline repletion on forward and<br /><br>backward waves in supine position and after standing</p><br>