Imaging Microcirculation And Gross hemodynamic assessment of the bowel during Elective colorectal Surgery

Completed

Conditions: gastrointestinal microcirculation
gastrointestinal microvascularisation
10017998

Registration Number: NL-OMON42295

Lead Sponsor: Sint Antonius Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 70

Inclusion Criteria

All patients aged >18 scheduled for elective, gastrointestinal surgery (as described above) with signed informed consent.

Exclusion Criteria

Age <18 years;
Atrial fibrillation (because of possible interference with FloTrac*/Vigileo* cardiac output monitor);
Left ventricular ejection fraction *30%;
Serious pulmonary disease (resting pO2 <90% at room air);
Renal failure (clearance <30 ml/min as calculated using the Modification of Diet in Renal Disease formula);
Liver failure;
No signed informed consent.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To describe human gastrointestinal microcirculation on both the serosal and<br /><br>mucosal side of the bowel during gastrointestinal surgery under general<br /><br>anesthesia. Main parameter: Microvascular perfusion is quantified using the<br /><br>Microvascular Flow Index (MFI).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Perfused vessel density (PVD), proportion of perfused vessels (PPVs), en<br /><br>heterogeneity of the microcirculation. To observe the possible correlation<br /><br>between bowel microcirculation and systemic hemodynamic parameters. MFI, PVD,<br /><br>PPV and indices of heterogeneity are compared between sides and to systemic<br /><br>hemodynamic parameters such as blood pressure, and if accessible, cardiac<br /><br>output (CO), stroke volume (SV) and stroke volume variation (SVV). These latter<br /><br>parameters are automatically measured by the FloTrac/Vigileo and thus only<br /><br>accessible when an arterial catheter is inserted.</p><br>