aser Speckle Imaging of blood flow in the microcirculation of the cerebral cortex
- Conditions
- function of the microcirculation in the cerebral cortex10029211
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
All patients that will undergo an awake craniotomy will be eligible for protocol A. They have to be at least 18 years old and there has to be informed consent.
All patients that will undergo a craniotomy under anaesthesia are eligible for protocol B. They have to be at least 18 years old and there has to be informed consent.
Exclusion Criteria
-
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The aim of the study is two-sided. First we propose to investigate and further<br /><br>develop the use of LSI to asses blood flow changes coupled to neuronal<br /><br>activities and to find out whether this approach can be used during tumor<br /><br>dissection. Secondly we aim to investigate the effects of several therapeutic<br /><br>standard interventions (infusion of mannitol, artificial elevation of mean<br /><br>arterial pressure and placement of surgical devices), which are expected to<br /><br>influence CBF, and are routinely used during neurosurgical procedures on<br /><br>microcirculatory flow in the brain, with and without the use of Transcranial<br /><br>Doppler Ultrasound to compare blood flow velocity in the microvasculature with<br /><br>the larger cerebral arteries.</p><br>
- Secondary Outcome Measures
Name Time Method <p>nvt</p><br>