Global, regional and microvascular hemodynamics during fluid resuscitation following cardiac surgery, a pilot study.

Phase 4

Recruiting

• Conditions: Hemodynamische instabiliteit; 1) Hemodynamic optimisation following CABG and/or heart valve replacement/repair. 2) Optimisation of blood flow after heart surgery.

• Registration Number: NL-OMON46111
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Age > 18 years
ICU admission following elective cardiac surgery
Undergoing cardiac output monitoring with a Pulmonary Artery Catheter
Need for fluid resuscitation as determined by the treating intensivist

Exclusion Criteria

Pregnancy
Renal failure (eGFR < 60ml/min/1.73 m2 or on RRT)
Iodide allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Renal perfusion: &delta;a.u./&delta;CI<br /><br>- &delta;a.u. (arbitrary units) obtained by CEUS, expressed in percentages<br /><br>- &delta;CI (cardiac index) obtained by swan ganz, expressed in CO/m2 = (mL<br /><br>blood/minute)/m2<br /><br><br /><br>Hepatic perfusion: &delta;PDR/&delta;CI<br /><br>- &delta;PDR (plasma disappearance rate) obtained by LiMON, expressed in<br /><br>percentage/minute.<br /><br><br /><br>- Distribution and clearance of infused fluids by kinetic model analysis,<br /><br>estimating Vc, k10, k12, and k21 using hemoglobin sampling during and after<br /><br>infusion.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>