Hemodynamics and Cutaneous Microcirculation during the Induction of General Anesthesia With and Without Esketamine

• Conditions: I95.2; I97.9; T88.5; Hypotension due to drugs; Postprocedural disorder of circulatory system, unspecified; Other complications of anaesthesia

• Registration Number: DRKS00022440
• Lead Sponsor: Klinik für Anästhesiologie und IntensivtherapieUniversitätsklinikum Carl Gustav Carus

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-07-23
• Study Start: 2020-12-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Medical necessity of invasive blood pressure monitoring (i.e. inserting arterial line) prior to the induction of general anesthesia.

Exclusion Criteria

- age < 18 years
- pregnancy
- body weight > 120 kg
- ASA score > 4
- emergency operation
- hemodynamic instability requiring medical intervention prior to induction (vasopressors, inotropes etc.)
- cerebrovascular disease
- known carotid stenosis
- LVEF < 30%
- COPD GOLD 4
- CKD with creatinine > 2,25 mg/dl or need for chronic dialysis
- liver cirrhosis CHILD B oder C
- ACS = 3 months prior
- acute hematological malignancy (acute leukemias, lymphomas)
- ongoing chemotherapy
- history of Raynaud's syndrome
- systemic sclerosis
- systemic vasculitides
- peripheral artery disease

additional exclusion criteria for patients receiving esketamine:
- hyperthyroidism
- ACS = 12 months prior
- PCI or CABG = 12 months prior
- hydrocephalus
- schizophrenia
- depression
- substance use disorders
- bipolar disorder
- blood pressure > 190 mmHg systolic upon arrival in the holding bay

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effects of the addition of esketamine to a standardized induction protocol on cutaneous microcirculation (via laser doppler flowmetry, distal-proximal gradient and capillary refilling time).

Secondary Outcome Measures

Name	Time	Method
Effekts of the addition of esketamine to a standardized induction protocol on cardiac output (via pulse contour analysis), mean arterial blood pressure and necessary dose of noradrenaline per kilogram of body weight to maintain normal blood pressure.