Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome
Completed
- Conditions
- Severe multiple organ dysfunction syndromeInjury, Occupational Diseases, PoisoningMultiple organ failure
- Registration Number
- ISRCTN52577337
- Lead Sponsor
- Innsbruck Medical University (Austria)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
Critically ill patients suffering of severe multiple organ dysfunction syndrome after cardiac or major surgery with a mean arterial blood pressure less than 65 mmHg despite adequate volume resuscitation, and Norepinephrine (NE) requirements greater than 0.5 µg/kg/min.
Exclusion Criteria
Patients with arterial vascular occlusive disease or insulin-dependent diabetes mellitus.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in the area under the concentration-time Area Under Curve (AUC) of the Doppler signal and the reactive hyperemic response to forearm ischaemia between AVP/NE and NE patients.
- Secondary Outcome Measures
Name Time Method Differences in the oscillation frequency of the Doppler signal between groups.