Skin Autofluorescence and Capillary Permeability: Relevance of Measuring Advanced Glycation Endproducts in Critically Ill Patients
Recruiting
- Conditions
- blood born infectionlung infection100276651000225210024970
- Registration Number
- NL-OMON31778
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 98
Inclusion Criteria
1. Written informed consent from close relative
2. Age > 18 years
3. Patient meets the general criteria for severe sepsis or septic shock, diagnosed less than 24 h prior to study inclusion.
4. and patients meets the general criteria for pneumonia.
5. Systemic arterial catheter in place with continuous pressure monitoring.
6. Patients in whom the clinician is prepared to provide full life support during the duration of the study.
Exclusion Criteria
1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury etc.)
2. Liver cirrhosis
3. (Insulin-dependent) diabetes mellitus
4. Patients on dialysis (CVVH or other)
5. Pre-existent urea cycle disorders or renal failure
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Survival rate in patients with severe septic shock and relationship with AGEs<br /><br><br /><br>2. Relationship of AGEs as measured in tissue, blood and as measured using the<br /><br>autofluorescence reader.<br /><br><br /><br>3. Relationship between sublingual microcirculation (and reversibility) and<br /><br>multi organ failure in septic patients. </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Relationship between AGEs and capillary permeability in patients with sepsis<br /><br><br /><br>2. Relationship between AGEs and oxidative stress. </p><br>