Can skin autofluorescence become a risk indicator for retinal detachment ?

Completed

• Conditions: retinal ablation or detachment; 10047060

• Registration Number: NL-OMON35809
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

• Willingness to participate.
• (Post-) vitrectomy patients, previously diagnosed with retinal detachment.
• Age: >18 years.

Exclusion Criteria

• Unwillingness to participate.
• Dark coloured skin (Fitzpatrick type V or VI).
• Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement.
• Local or general active infection or inflammatory disease.
• Known renal disease, current dialysis treatment, or a history of renal transplantation.;Exclusion criteria only for the pilot study
• Known diabetes mellitus.
• Pre-existing cardio-vascular complications
• Intra-ocular implant lens.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint: the relation between skin AF,vitreous body AGE levels, and<br /><br>plasma AGE levels. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoint: relation between vitreous body AGE levels and severity of<br /><br>retinal detachment.<br /><br>Other study parameters: verbally asked questions about cardiovascular history,<br /><br>concomitant disease and medication, and current and previous smoking habits</p><br>