The role of skin autofluorescence as a predictor for post-operative proliferative vitreoretinopathy and surgical failure in patients with retinal detachment
Completed
- Conditions
- (rhegmatogenous) retinal detachment10047060
- Registration Number
- NL-OMON38541
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
• Willingness to participate.
• Patients, diagnosed with retinal detachment, scheduled for vitrectomy.
• Age: >18 years.
Exclusion Criteria
• Dark coloured skin (Fitzpatrick type V or VI).
• Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement.
• Local or general active infection or inflammatory disease.
• Known renal disease with impairment of renal function class CKD >=3 (<= 60 ml/min according to eGFR), current dialysis treatment, or a history of renal transplantation.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- The relation between skin AF and failure of surgery for retinal detachment<br /><br>- The relations between skin AF and PVR (pre- and postoperative), vitreous body<br /><br>AGE and sRAGE levels, plasma sRAGE levels and glyoxalase and RAGE<br /><br>polymorphisms. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Relation between surgical failure and clinical risk factors for post-operative<br /><br>PVR.</p><br>