Skin autofluorescence and surgical failure in retinal detachment patients
Completed
- Conditions
- Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition, most often initiated by a posterior vitreous detachment-associated retinal tear. A recent study found an incidence of RRD in the Netherlands of 18.2 per 100,000 people.
- Registration Number
- NL-OMON27827
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
1. Willingness to participate.
2. Patients, newly diagnosed with retinal detachment, scheduled for vitrectomy.
Exclusion Criteria
1. Dark coloured skin that impairs the reliability of the autofluorescence measurement.
2. Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Surgical failure
- Secondary Outcome Measures
Name Time Method 2. Skin autofluorescence<br /><br>3. Vitreous body AGE levels<br /><br>4. Vitreous body sRAGE levels<br /><br>5. plasma sRAGE levels<br /><br>6. Glyoxalase polymorphisms<br /><br>7. RAGE polymorphisms<br /><br>8. Age, <br /><br>9. gender, <br /><br>10. surface area of retinal detachment, <br /><br>11. number of retinal defects, <br /><br>12. macular detachment, <br /><br>13. detachment duration, <br /><br>14. pre-operative PVR grade, <br /><br>15. presence of diabetes, <br /><br>16. pseudophakia, <br /><br>17. intraoperative use of gas or silicon oil, <br /><br>18. intraoperative cryotherapy, intraoperative minor hemorrhage.