Empirical hemodynamic models of micro- and macro-vessels in the brain: an fMRI and RespirActTM approach
Recruiting
- Conditions
- Een specifieke aandoening maakt geen onderdeel uit van dit onderzoek (gezonde vrijwilligers).Na (healthy volunteers)
- Registration Number
- NL-OMON45408
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 56
Inclusion Criteria
- Informed consent;
- 18 years or older.
Exclusion Criteria
Part I (fMRI with RespirAct):
- Standard contra-indications for 3T or 7T MRI scanning;
- Unwilling or unable to co-operate with breathing manoeuvres;
- Respiratory or cardiac limitations to breathing at 20 L/min;
- Medical contra-indications to limited hypercapnia or hypocapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis);
- Known vascular brain disease.;Part II (fMRI without RespirAct):
- Standard contra-indications for 3T or 7T MRI scanning.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Establishment and modelling (quantification) of hemodynamic changes for<br /><br>different vessel groups in the human brain in response to external stimulation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>