Different prescribed doses of high volume peritoneal dialysis and outcome of patients with acute kidney injury
- Conditions
- Acute Kidney InjuryUrological and Genital Diseases
- Registration Number
- ISRCTN52811271
- Lead Sponsor
- São Paulo State University (Universidade Estadual Paulista [UNESP]) (Brazil)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
1. Adults with Acute Kidney Injury (AKI) according to Acute Kidney Injury Network (AKIN) criteria
2. Clinical diagnosis of severe acute tubular necrosis (ATN) caused by a recent ischemic or nephrotoxic injury. Severe ATN was defined as a history of prolonged and profound hypotension, severe nephrotoxic drugs overdose, or excess endogenous nephrotoxic pigments (hemoglobinuria, myoglobinuria). Diagnosis was based on clinical history, results of physical examination, relevant blood tests, and urinalysis (microscopical examination of urinary sediment), a fractional excretion of sodium that exceeded 1% and the findings on renal ultrasonography.
1. Under 18 years of age
2. Functional azotemia
3. Urinary tract obstruction
4. Acute interstitial nephritis
5. Rapidly progressive glomerulonephritis
6. History of chronic renal insufficiency (serum creatinine 43mg per 100 ml)
7. Renal transplantation
8. Pregnancy
9. Severe hypercatabolism according to Scherier criteria
10. Absolute contraindication for PD were recent abdominal surgery (less than one month)
11. Multiple abdominal surgeries (more than three)
12. Patients submitted to less than one session of high volume PD (HVPD), defined as 24 h.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death within 30 days
- Secondary Outcome Measures
Name Time Method 1. Recovery of kidney function within 30 days<br>2. Metabolic control