NCT00660491CompletedPhase 2
Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise
Norwegian University of Science and Technology1 site in 1 country8 target enrollmentStarted: January 1, 2008Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Flow mediated dilatation
Study Overview
Brief Summary
Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.
Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 20 Years to 40 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •male, 20-40years, BMI between 25 and 30, resident in Trondheim.
Exclusion Criteria
- •unstable angina, CHD, heart failure,
Arms & Interventions
1
No Intervention
Control
2
No Intervention
moderate exercise training group
3
Experimental
high intensity exercise group
Intervention: exercise training (Other)
Outcomes
Primary Outcomes
Flow mediated dilatation
Time Frame: baseline, post exercise, 30min, 2hour, 4hour post exercise
Secondary Outcomes
- blood lipid profile(same as flow mediated dilatation)
Investigators
Study Sites (1)
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