Kinetics of Plasma Fibrinogen in Cardiac Surgery
Completed
- Conditions
- Fibrinogens, Abnormal
- Registration Number
- NCT02605330
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
The study intends to measure fibrinogen plasma levels during the first 24 hrs in cardiac and thoracic surgical patients who undergo surgical procedures using extracorporeal circulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- Elective patients undergoing coronary artery bypass grafting, aortic valve replacement or thoracic aortic surgery
- Signed written informed consent
Exclusion Criteria
- Participation in another study
- Language barrier to understand study purposes (e.g. french as a native language)
- Preoperative low level of plasma fibrinogen (< 1.75 g/l)
- Preoperative anemia (Hb < 10g/dl)
- Emergency treatment
- Intake of anticoagulants other than aspirin within 14 days preceding surgery.
- Known coagulation disorder.
- Jehovah's witnesses
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma fibrinogen concentration through study completion, an average of 1 year Conventional (Clauss) and thromboelastometric measurement (FIBTEM)
- Secondary Outcome Measures
Name Time Method Periprocedural thromboembolic complications through study completion, an average of 1 year In-hospital mortality through study completion, an average of 1 year Platelet count through study completion, an average of 1 year Measurement of platelet count in the laboratory
Prothrombin time (Quick) through study completion, an average of 1 year Measurement of Quick in the laboratory
Thoracic drain loss through study completion, an average of 1 year Measurement of the amount of blood collected by the thoracic drain (ml)
Intensive Care Unit (ICU) length of stay through study completion, an average of 1 year Thrombin concentration through study completion, an average of 1 year Thrombin concentration in the plasma as measured in the laboratory
Activated partial thromboplastin time (aPTT) through study completion, an average of 1 year Measurement of aPTT in the laboratory
Thromboelastometric (ROTEM) parameters (e.g., INTEM, EXTEM, HEPTEM) through study completion, an average of 1 year Measurement of ROTEM parameter (unit mm) in the laboratory
Trial Locations
- Locations (1)
University Hospital Bern
🇨🇭Bern, Switzerland
University Hospital Bern🇨🇭Bern, Switzerland