EUCTR2005-001660-31-GBActive, not recruitingPhase 1
A Prospective Randomized Controlled Trial of Morphine versus Oxycodone for Cancer Pain: Genetic Determinants of Response to Opioids. - RCT Morphine vs Oxycodone: Genetics Study
The Royal Marsden Hospital NHS Foundation Trust0 sites0 target enrollmentStarted: July 7, 2005Last updated:
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Status
- Active, not recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
Inclusion Criteria
- •Inclusion Criteria
- •Patients must have a clinical or histological diagnosis of cancer.
- •Patients whose pain is not controlled on Step 2 analgesics (as defined by the WHO analgesic ladder) who clinically require a strong opioid.
- •Patients must be over 18 years of age.
- •Patients must be able to give written informed consent.
- •Patients must be willing to undergo genetic screening
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
Exclusion Criteria
- •Exclusion Criteria
- •Patients with renal failure (1.5x ULN). These patients should be treated with alfentanil as per palliative care guidelines.
- •Patients must not have been taking regular Step 3 analgesics in the last month.
- •Patients requiring parenteral administration of opioids.
- •Patients with predominantly neuropathic pain.
- •Patients with predominantly incident pain
- •Patients with a clearly defined history of intolerance to morphine or oxycodone.
Investigators
Similar Trials
Completed
Not Applicable
A Prospective Randomized Controlled Trial of Morphine versus Oxycodone for Cancer Pain: Genetic Determinants of Response to OpioidsModerate to severe cancer painPainCancerISRCTN65155201The Royal Marsden NHS Foundation Trust (UK)200
Recruiting
Phase 3
Comparison of Results between Open Carpal Tunnel Release and Minimally Invasive Carpal Tunnel Release in Carpal Tunnel Syndrome PatientsPain scoreOpen carpal tunnel releaseMinimally invasive carpal tunnel ReleaseCarpal tunnel syndromeTCTR20220914002/A90
Completed
Not Applicable
A Prospective Randomised Controlled Trial of the Immediate Post-operative Intra-articular Local Anaesthetic Infusion Using Infusion Pump in Total Knee Arthroplasty.PainSigns and Symptoms: PainSigns and SymptomsISRCTN32365985Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)50
Recruiting
Phase 3
A Prospective Randomized Controlled Clinical Trial of Prophylactic Cranial Irradiation in Metastatic HER-2 positive Breast Cancer.Metastatic HER-2 positive breast cancer patientsRisk of brain metastasisHER2 positivePCIMetastatic breast cancerTCTR20170612001Ratchadapiseksompotch research fund235
Completed
Not Applicable
A study to assess the effectiveness of Ayurvedic formulation Guduchi Ghan vati in Covid-19 casesCTRI/2020/07/026840Directorate of AYUSH Government of Madhya Pradesh30