MTHFR-Gene Polypmorphisms and its prognostic impact for response of radiochemotherapy in rectal cancer
Recruiting
- Conditions
- C20Malignant neoplasm of rectum
- Registration Number
- DRKS00022818
- Lead Sponsor
- niversitätsklinik für Allgemein- Viszeral und Thoraxchiirurgie, Proktologie der RUB
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
histological verified rectal cancer within stage II-III //
signed declaration of consent
Exclusion Criteria
patients without complience or patinents who are not able to travel for repetitive examinations to hospital //
patients younger than 18 years //
pregnant or brestfeeding mothers //
secondary carcinomas //
persons who are to be kept in an institution by judicial or official order
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome of the study is genotype at SNP rs1801133 and rs 1801131. All patients from arm 1 and 2 will be genotyped at this locus after operation. Genotyping will be done by pyrolysis sequencing.<br>
- Secondary Outcome Measures
Name Time Method 1. tumor-free survival rate<br><br>2. overall survival<br>