Arterial Remodeling in Smokers

Completed

• Conditions: FMD; IMT; Smoking
• Interventions: Procedure: smoke expose

• Registration Number: NCT01862146
• Lead Sponsor: Klinik für Kardiologie, Pneumologie und Angiologie

Brief Summary

Cigarette smoking is the most important modifiable cardiovascular risk factor leading to endothelial dysfunction and was suggested to impair arterial regeneration.The aim of the study was to investigate the effect of smoking on vascular response to transradial coronary angiography (TCA).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-05-22
• Study First Submitted QC: 2013-05-23
• Study First Posted: 2013-05-24
• Status Verified: 2014-06
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Last Update Submitted: 2014-06-03
• Last Update Posted: 2014-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• all subjects underwent a TCA

Exclusion Criteria

• acute inflammation cardiac arrhythmia renal failure heart failure (NYHA II-IV) CRP > 1 mg/dl malignant disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Current Smoker underwent TCA	smoke expose	subjects who smokes daily

Primary Outcome Measures

Name	Time	Method
IMT hyperplasia	change in radials IMT after 6-14 month after a TCA	IMT is measured by high resolution ultrasound in the radial arteries.

Secondary Outcome Measures

Name	Time	Method
Endothelial function	change in flow mediated dilatation after 10-14 months	Flow mediated dilatation (FMD)

Trial Locations

Locations (1)

Division of Cardiology, Pulmonology and Vascular Medicine Duesseldorf,; 🇩🇪 Duesseldorf, NRW, Germany