IRCT2013012610817N3
Completed
未知
Pharmacokinetic of intamuscular and intravenous methadone in critically ill patients
Tehran University of Medical Siences0 sites40 target enrollmentStarted: TBDLast updated:
Conditionscritically ill patients in ICU.
Overview
- Phase
- 未知
- Status
- Completed
- Sponsor
- Tehran University of Medical Siences
- Enrollment
- 40
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 years to 65 years (—)
- Sex
- All
Inclusion Criteria
- •Inclusion criterion: critically ill patients in ICU, who require pain management with opioids.
- •Exclusion criteria: hypersensitivity to methadone or any component of the formulation; patients older than 65 years old; patients with renal failure( Scr \> 2mg/dl ,Urine Output \<0\.5cc/kg/hour) 4\. ); patients with hepatic failure(hepatic enzymes more than 3 times normal); patients with Platelet less than 100000; mean arterial pressure less than 65 or who require inotrope or vasopressor and patient who suffer ALI (PaO2 /FIO2\<300\).
Exclusion Criteria
- Not provided
Investigators
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