Assessing blood levels of ketorolac ( Toradol) injected in around the hip and knee joints in patients undergoing joint replacements

Not Applicable

Completed

• Conditions: Blood levels of analgesics; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12613000923763
• Lead Sponsor: Dr.Usha Gurunathan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-08-21
• Study Completion: 2014-12-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Should be able to speak and understand English
Should be able to give an informed consent
Patients > 18 yrs of age
Both Male and female patients undergoing Total Hip and Total Knee Replacements
All patients should have normal renal function
Participating patients should have no systemic diseases which include severe heart/lung conditions/bleeding disorders
Not on any medications which could alter renal function
Patients will not receive any further NSAID’s in the first 24 hrs of surgery

Exclusion Criteria

Patients < 18 yrs of age
Consent not obtained
Impaired renal function
Patients with severe cardiovascular / lung diseases
Pregnancy/lactation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum levels of ketorolac will be analysed using High-performance liquid chromatography (HPLC) at Biochemical laboratory, University of Queensland.[30 mins, 1,2,4,8 and 24 hours post infiltration]

Secondary Outcome Measures

Name	Time	Method
Postoperative day 1 routine blood tests: full blood count, serum urea, creatinine, electrolytes and glomerular filtration rate[ first postoperative day]