Inhibition Control of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Attention Deficit Hyperactivity Disorder
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 60
- Locations
- 1
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The objectives of this study are to investigate:
- the effect of methylphenidate on attention;
- the relations between methylphenidate and inhibition control and working memory;
- the relations between inhibition control and verbal attention and working memory;
- the effect of methylphenidate on the changes of neuropsychological functioning and blood pressure.
Detailed Description
Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity and impulsivity, is an early onset, highly heritable, clinically heterogeneous, long-term impairing disorder with tremendous impact on individuals, families, and societies. It affects 5-10% of school-aged children worldwide (7.5% in Taiwan). Methylphenidate, a stimulant, is effective in treating these patients. Studies in Taiwan show no effect of methylphenidate on blood pressure. There are evidences show that the change of blood pressure was associated with inhibition of impulsive behaviors. Stop Signal Task(SST) is used to assess the improve of inhibition control after methylphenidate response. By using repeated outcome measurements, we anticipate that this study will evaluate the improvement of neuropsychological performances after medication and determinie the association between medication response and neuropsychological functions and vital signs in a Taiwanese sample.
Investigators
National Taiwan University Hospital
Susan Shur-Fen Gau
National Taiwan University Hospital
Eligibility Criteria
Inclusion Criteria
- •The inclusion criteria for the subjects are (1)that subjects have a clinical diagnosis of ADHD defined by the DSM-IV which was made by a full-time board-certificated child psychiatrist; (2)their ages range from 10 to 18 when we conduct the study; (3)their IQ greater than 80; and (4)they are under treatment of methylphenidate.
Exclusion Criteria
- •The subjects will be excluded from the study if they currently meet criteria or have a history of the following condition as defined by DSM-IV: Schizophrenia, Schizoaffective Disorder, Organic Psychosis, or Pervasive Developmental Disorder.
Outcomes
Primary Outcomes
Not specified