The impact of REStrictive versUs Liberal Transfusion strategy on cardiac injury and death in patients undergoing surgery for Hip Fracture (RESULT-Hip)

niversity of Edinburgh and NHS Lothian Health Board0 个研究点目标入组 1,964 人开始时间: 2022年5月3日最近更新: 2024年8月5日

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•Current participant inclusion criteria as of 17/11/2023:
•1. Adults aged 60 years or over
•2. Admission to acute unit for operative management of hip fracture
•For Randomisation:
•3. Presence of anaemia (Haemoglobin equal to or less than 90 g/L) at any point between the date of admission to hospital up to and including seven days after surgery
•Previous participant inclusion criteria:
•1. Adults aged 60 years or over
•2. Admission to hospital for operative management of hip fracture
•For Randomisation:
•3. Presence of anaemia (Haemoglobin equal to or less than 90 g/L) at any point between the date of admission to hospital up to and including seven days after surgery

•Current participant inclusion criteria as of 17/11/2023:
•1. Objection to RBC transfusion
•2. Unable to obtain consent (from patient or in accordance with appropriate mental capacity legislation for site)
•3. Patients for non-operative management or not expected to survive 48 hours
•4. Patients with a new or suspected acute coronary syndrome meeting 4th Universal Definition during current admission
•5. Rapid or uncontrolled blood loss resulting in haemodynamic instability
•6. Transfusion dependent/chronic anaemias (eg Myelodysplasia or bone marrow failure syndromes)
•Previous participant inclusion criteria:
•1. Objection to RBC transfusion
•2. Unable to obtain consent (from patient or in accordance with appropriate mental capacity legislation for site)
•3. Patients for non-operative management or not expected to survive 48 hours
•4. Patients with a new acute coronary syndrome meeting 4th Universal Definition during current admission
•5. Rapid or uncontrolled blood loss resulting in haemodynamic instability

发起方

niversity of Edinburgh and NHS Lothian Health Board