Pulmoner Hipertansiyon gelişmiş Bronkopulmoner Displazili Pretermlerin Ekokardiyografik ve Biyokimyasal değerIendirilmesi
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 59
- 主要终点
- Serum kallistatin level
研究概览
简要总结
Pulmonary hypertension may develop in premature newborn infants due to impaired lung development. The diagnosis of this disease can actually be made with interventional methods.
In this study, we evaluated the importance of echocardiographic examination and blood laboratory tests in diagnosing this disease.
详细描述
Bronchopulmonary dysplasia diagnosis was done by the same neonatologist according to the criteria published by the American National Institutes of Health (NIH) in 2001.
Demographic data of patients like: birth weight, gender, gestational age; neonatal morbidity like: surfactant administration, PDA and its treatment, duration of mechanical ventilation, diuretic usage, intraventricular hemorrhage and its grade, necrotizing enterocolitis (NEC) and its severity, any surgical procedures and late-onset sepsis were recorded.
Moreover; maternal and perinatal risk factors like presence of chorioamnionitis, maternal hypertension and administration of antenatal steroids were also recorded.
Echocardiography:
Echocardiographic measurements were performed with a GE Vivid-7 pro equipped with a 3-7 MHz for 2-dimensional and color flow Doppler mapping by the same pediatric cardiologist.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 28 Days 至 3 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Born ≤ 28 postmenstrual weeks
- •Respiratory support persisting at 36 weeks corrected postmenstrual age.
- •Echocardiographic examination consistent with pulmonary hypertension
- •BPD patients without PHT
- •Inclusion Criteria:
- •Born ≤ 28 postmenstrual weeks
- •Respiratory support persisting at 36 weeks corrected postmenstrual age.
- •Normal echocardiographic examination
- •Healty preterms
- •Born ≤ 28 postmenstrual weeks
- •Do not need respiratory support persisting at 36 weeks corrected postmenstrual age
- •Normal echocardiographic examination
排除标准
- •Congenital heart disease (with the exception of patent ductus arteriosus or patent foramen ovale)
- •Structural lung and airway malformations (including tracheobrochomalacia)
- •Congenital diaphragmatic hernia
- •Chromosome abnormality
结局指标
主要结局
Serum kallistatin level
时间窗: 1 month
Serum kallistatin level is effective in diagnosing pulmonary hypertension in preterms with bronchopulmonary dysplasia and is consistent with the clinical findings of the patients.
Echocardiographic examination
时间窗: 1 month
Echocardiographic examination is effective in diagnosing pulmonary hypertension in preterms with bronchopulmonary dysplasia and is consistent with the clinical findings of the patients.
次要结局
未报告次要终点
研究者
süleyman sunkak
Specialist (pediatric cardiolog)
Kayseri City Hospital