NEURodevelopmental Outcome in Children Between One and Five Years After Persistent Pulmonary Hypertension Of the Newborn
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Persistent Pulmonary Hypertension of the Newborn
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 55
- Locations
- 1
- Primary Endpoint
- Describe the association between the occurrence of neuro-psychomotor developmental disorders and initial management in resuscitation.
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Neonatal pulmonary hypertension is a rare but serious condition resulting from a lack of adaptation to extra-uterine life in some newborns. In the short term, the risk of death requires rapid and appropriate management of this transient pathology.
In the long term, these newborns present a greater brain vulnerability, a consequence of the pathology itself with cerebral hypoxia but also invasive and aggressive therapies. Although current scientific evidence indicates a correlation with the existence of neurological developmental disorders, the understanding of the long-term neurological outcome of these babies remains poorly documented. Better knowledge of remote neuro-psychomotor development of the critical period
Investigators
Eligibility Criteria
Inclusion Criteria
- •All parenting authority holders of children aged 1 to 5 years, born after 34 weeks of amenorrhea and having been cared for neonatal PAH in paediatric resuscitation
Exclusion Criteria
- •Holders of parental authority who cannot answer the questionnaire because they do not speak French.
- •Opposition of one of the two holders of parental authority
- •Minor parental authority holders
- •Holders of parental authority under safeguarding of justice, guardianship or guardianship
- •Newborns with neonatal PAH with an associated diagnosis of diaphragmatic hernia or cyanogenic congenital heart disease
- •Newborns with neonatal PAH not treated with nitrogen monoxide
Outcomes
Primary Outcomes
Describe the association between the occurrence of neuro-psychomotor developmental disorders and initial management in resuscitation.
Time Frame: Between one and 5 years after hospitalization in resuscitation.
Parents will complete ASQ3. The investigators will consider neuro-psychomotor developmental disorders in children with pathological ASQ questionnaire on at least 2 items.