The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

Completed

• Conditions: Umbilical Cord; Anesthesia, General; Anesthesia, Spinal
• Interventions: Other: General anesthesia; Other: Spinal anesthesia

• Registration Number: NCT05409885
• Lead Sponsor: Antalya Training and Research Hospital

Brief Summary

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Detailed Description

This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section.

The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Study Timeline

• Study Start: 2022-03-20
• Status Verified: 2022-04
• Study First Submitted: 2022-04-20
• Study First Submitted QC: 2022-06-04
• Study First Posted: 2022-06-08
• Primary Completion: 2022-07-01
• Study Completion: 2022-07-07
• Last Update Submitted: 2022-07-20
• Last Update Posted: 2022-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 18 - 45 years
• American Society of Anesthesiology (ASA) II-III
• elective ceserean surgery

Exclusion Criteria

• declining to give written informed consent
• under 18 years of age or over 45 years of age
• factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
• history of neurological and/or neuromucular disease
• cooperation cannot be established
• emergency surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
General anesthesia group	General anesthesia	Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.
Spinal anesthesia group	Spinal anesthesia	Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Primary Outcome Measures

Name	Time	Method
neutrophil-to-lymphocyte ratio	within 5 minute, following delivery	Evaluate the effects of NLR in patients undergoing cesarean section

Secondary Outcome Measures

Name	Time	Method
Newborn Apgar score 1st minute	1st minute after birth	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)
platelet-to-lymphocyte ratio	within 5 minute, following delivery	Evaluate the effects of PLR in patients undergoing cesarean section
mean platelet volume	within 5 minute, following delivery	Evaluate the effects of MPV in patients undergoing cesarean section
Newborn Apgar score 5th minute	5th minute after birth	Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)

Trial Locations

Locations (1)

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation; 🇹🇷 Antalya, Turkey