Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Cortisol levels in 4 biologicals fluids
研究概览
简要总结
Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have limitations.
Therefore, a non-invasive and ambulatory method would be useful to measure cortisol levels in real-time.
The main aim of the study is to compare cortisol levels across biological fluids (sweat, saliva, interstitial fluid, and blood) in order to validate in the long term a continuous and non-invasive cortisol measurement device (currently under development).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 30 years old
- •normal BMI 18 to 25 kg/m2
- •weight stability
排除标准
- •pregnancy, breastfeeding, irregular menses
- •any medical treatment
- •any medical issues
- •pilocarpine allergy, or latex allergy
- •glaucoma or acute irritis
结局指标
主要结局
Cortisol levels in 4 biologicals fluids
时间窗: 24 hours
Comparison of cortisol levels in these 4 biological fluids
次要结局
- Aldosterone levels in 4 biological fluids(24 hours)
- Mineralocorticoid - comparison of repeated measures of aldosterone concentrations profiles - over a period of 24 hours(24 hours)
- Glucocorticoid - comparison of repeated measures of glucocorticoid concentrations (cortisol, 18OHF, cortisone) profiles - over a period of 24 hours(24 hours)
研究者
Nelly Pitteloud
Professor
Centre Hospitalier Universitaire Vaudois