Salivary Cortisol Measurements by Mass Spectrometry

Completed

• Conditions: Endocrine Disorders

• Registration Number: NCT02162706
• Lead Sponsor: Stanford University

Brief Summary

Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.

Detailed Description

Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2014-06-11
• Study First Submitted QC: 2014-06-12
• Study First Posted: 2014-06-13
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-08
• Last Update Posted: 2019-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Normal subjects
• Subjects with possible endocrine disorder

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Exclusion Criteria

• Tracheostomy or ventilator dependent
• Gastrotomy tubed dependent or unable to eat/drink by mouth

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Salivary Cortisol	All collections are done within 48 hours

Trial Locations

Locations (1)

Lucile Packard Children's Hospital and Stanford Clinics; 🇺🇸 Stanford, California, United States