Pilot Study of Salivary Cortisol Measurements by Mass Spectrometry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Salivary Cortisol
研究概览
简要总结
Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace measurements by blood.
详细描述
Cortisol levels change depending on the time of day. Salivary samples were collected from health controls at bedtime, midnight and first morning waking on two consecutive nights and salivary cortisol levels were measured using mass spectrometry. In a patients with possible endocrine disorders who were going through an adrenocortiotropin stimulation test for adrenal insufficiency, salivary cortisol was measured prior to giving cosyntropin and 30-40 minutes after cosyntropin.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 3 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal subjects
- •Subjects with possible endocrine disorder
排除标准
- •Tracheostomy or ventilator dependent
- •Gastrotomy tubed dependent or unable to eat/drink by mouth
结局指标
主要结局
Salivary Cortisol
时间窗: All collections are done within 48 hours
次要结局
未报告次要终点
研究者
Tandy Aye
Associate Professor
Stanford University