Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Slit Intercostals Nerve Block for Chronic Post-thoracotomy Pain:A Single Blind Randomized Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Acute and chronic postoperative pain
研究概览
简要总结
The patients were divided into two groups by random number method: GroupRD1 group and GroupRD2 group were given general anesthesia and intercostal nerve block.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml.
详细描述
The RD1 group received ultrasound-guided intercostal nerve block at the incision before anesthesia induction, and the RD2 group received ultrasound-guided intercostal nerve block at the lateral costal Angle before anesthesia induction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-70 years old
- •ASA grade I-III
- •BMI: 18.5-28kg/m2
- •Type of surgery: elective thoracoscopic lung mass resection
- •Informed consent has been signed by the patient and/or family members
排除标准
- •game anesthesia or sugar cortical hormone drugs allergic
- •preoperative use of opioid medicines
- •serious blood coagulation dysfunction
- •serious heart, lung, liver and renal insufficiency
- •put, chemotherapy, and glucocorticoid immunosuppressive therapy history or diseases of the immune system
- •peptic ulcer
- •newly gastrointestinal surgery
- •has a history of thoracic surgery
- •is the central nervous system disease
- •Other glucocorticoids should be used with caution in patients such as fractures, wound repair, corneal ulcers, hyperadrenocortical disease, diabetes mellitus, pregnant women, etc.
研究组 & 干预措施
intercostal nerve block at the incision
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
干预措施: intercostal nerve block (Other)
intercostal nerve block at the incision
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
干预措施: ropivacaine + compound betamethasone (Drug)
lateral intercostal nerve block at costal angle
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
干预措施: lateral intercostal nerve block (Other)
lateral intercostal nerve block at costal angle
General anesthesia and intercostal nerve block were performed.The drug for intercostal nerve block was 0.33% ropivacaine +2.333mg compound betamethasone (1.667mg betamethasone dipropionate + 0.667mg betamethasone sodium phosphate) to 15ml
干预措施: ropivacaine + compound betamethasone (Drug)
结局指标
主要结局
Acute and chronic postoperative pain
时间窗: 3 months after surgery
Numeric rating scale(NRS) is used to assess acute postoperative pain
次要结局
未报告次要终点
研究者
Yibin Qin
associate chief physician
Affiliated Hospital of Nantong University