A Real World Study of Yangxuenao Granules Reducing Bleeding Risk in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Microhemorrhage (CMB) of T2* sequence in MRI after thrombolysis
研究概览
简要总结
Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world
详细描述
Objective
To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world Study Design. This study was a single center real world study. Through the review data, this study included in January 1, 2017 to September 30, 2019, see a doctor at Peking University third hospital neurology, emergency diagnosis of acute ischemic stroke, and venous thrombolysis in patients with a queue, on the basis of whether the application have serum brain particles are divided into a group and the control group, serum application parameters and nonparametric comparison, K-M curve and Cox regression model were used to evaluate the effectiveness of Yangxuenao granules in reducing bleeding conversion after intravenous thrombolysis by comparing the number of microbleeding, stroke severity score and modified Rankin score after 3 months follow-up with the weighted craniocerebral magnetic sensitivity imaging sequence reexamined within 48 hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A cohort of patients admitted to the Department of Emergency Neurology at Peking University Third Hospital on January 1, 2017 and admitted on September 30, 2019, who were diagnosed with acute ischemic stroke and underwent intravenous thrombolysis.
排除标准
- •Patients who underwent intravenous thrombolysis but were confirmed to be apoplexy
- •like by imaging and other clinical examinations; Incomplete craniocerebral MRI examination;
- •Bridging endovascular therapy;
- •The previous application of Yangxuenao granules or other drugs with similar effects;
研究组 & 干预措施
The experimental group
The application of raising serum brain granules
干预措施: Raise serum brain granules (Drug)
The control group
No nourishing serum brain granules are used
干预措施: No nourishing serum brain granules are used (Drug)
结局指标
主要结局
Microhemorrhage (CMB) of T2* sequence in MRI after thrombolysis
时间窗: 1 day
The number of CMB is an important imaging marker reflecting microvascular injury.
次要结局
未报告次要终点