Surgical Stress and Intracorporeal Anastomosis
- Conditions
- Laparoscopic Right Colectomy
- Interventions
- Procedure: Laparoscopic right colectomy
- Registration Number
- NCT03422588
- Lead Sponsor
- Federico II University
- Brief Summary
The short-term advantages of minimally invasive colon resection have been well established in several randomized trials. A major factor in the development of morbidity is the surgical stress response with subsequent increased demand on the patient's reserves and immune competence. Although the advantage in term of stress response of laparoscopic surgery over open surgery has been widely reported, little is known about the role of Intracorporeal anastomosis.
In an attempt to evaluate the surgical stress response after totally laparoscopic right colectomy a comparative study has been designed.
Two surgical procedures will be evaluated:
* Totally laparoscopic right colectomy with intracorporeal anastomosis (Experimental group)
* Laparoscopic assisted right colectomy with extracorporeal anastomosis (Control group).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
All elective laparoscopic right colectomy for cancer
Urgent procedures Immune depressant therapy Immune depressant disease Post-operative Complications
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Extracorporeal Laparoscopic right colectomy Laparoscopic assisted right colectomy with extracorporeal anastomosis Intracorporeal Laparoscopic right colectomy Totally laparoscopic right colectomy with intracorporeal anastomosis
- Primary Outcome Measures
Name Time Method tumor necrosis factor alpha change between time before surgery, 24 hours after surgery, 72 hours after surgery interleukin 6 change between time before surgery, 24 hours after surgery, 72 hours after surgery adrenocorticotropic hormone change between time before surgery, 24 hours after surgery, 72 hours after surgery cortisol change between time before surgery, 24 hours after surgery, 72 hours after surgery glucagon change between time before surgery, 24 hours after surgery, 72 hours after surgery growth hormone change between time before surgery, 24 hours after surgery, 72 hours after surgery interleukin 1 change between time before surgery, 24 hours after surgery, 72 hours after surgery insulin change between time before surgery, 24 hours after surgery, 72 hours after surgery C-reactive protein change between time before surgery, 24 hours after surgery, 72 hours after surgery prolactin change between time before surgery, 24 hours after surgery, 72 hours after surgery fibrinogen change between time before surgery, 24 hours after surgery, 72 hours after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Naples Federico II
🇮🇹Naples, Italy