Gait control – visuo-motor interactions and plasticity in glaucoma

Not Applicable

Recruiting

Conditions: H40
Glaucoma

Registration Number: DRKS00022519

Lead Sponsor: Otto-von-Guericke Universität Magdeburg Universitäts-Augenklinik

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Patients: open angle glaucoma;
Controls: normal visual acuity

Exclusion Criteria

other eye diseases except of beginning cataract, ocular trauma, eye surgery (except cataract and glaucoma surgery), neurological and/or orthopedic diseases, e.g. advanced arthrosis, implants of lower extremities, visual acuity < 0.8 for controls

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the effect of uni- and multimodal movement-related intervention (60 min, 2/week, for 12 weeks), comparing pre- (within max. 4 weeks prior to intervention start) and postinterventional data (within max. 3 weeks post intervention end):<br><br>(a) fMRI-based functional connectivity:<br>Functional connectivity, quantified as seed-to-voxel and ROI-to-ROI correlations of BOLD time-series will be computed between relevant cortical regions as identified in Demirakca et al. (2016) including premotor, primary senso-motor, visual, auditory, dorsolateral prefrontal cortex, frontal eye-fields and midcingulate gyrus.<br><br>(b) Gait control: gait velocity, gait<br>variability (step lenght, MTC).

Secondary Outcome Measures

Name	Time	Method
Comparison within and across participant groups (controls vs glaucoma) and/or intervention groups (uni- and multimodal intervention) with respect to: <br>(a) fMRI results for functional connectivity, cortical visual field maps, task related responses.<br>(b) Results of eye-movements, cognitive, motor- and visual function, dual-task costs.<br>