Treatment of Chronic Relapsing Urinary Tract Infection With Bacteriophages in Renal Transplant Patients
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Urine culture
研究概览
简要总结
Urinary tract infections (UTIs) with extended-spectrum -lactamase (ESBL)-positive Enterobacteriums (ESBL-E) are a common infectious complication of renal transplant recipients, with 10% of patients suffering from UTIs with ESBL-E within the first year posttransplant. Moreover, recurrence rates of UTI caused by ESBL-E are almost three times higher than those by cephalosporin-susceptible Enterobacteriums demonstrating the decreased efficacy of antibiotics in the treatment of these UTIs.
详细描述
According to each patient's urine culture, resistant urinary tract infections will be treated with specific phages and patients will be followed up with their urine cultures for response to therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable Kidney Transplant Recipients
- •Stable Immunosupression Dose
- •Stable Renal Function
- •Resistant Urinary Infection with Positive UC
排除标准
- •Rejection periods
- •Frail Patients
研究组 & 干预措施
UC Positives
Stable Transplanted Patients with Positive UC
干预措施: Phage (Biological)
结局指标
主要结局
Urine culture
时间窗: 1 week after administration
Negative Urine Culture
次要结局
未报告次要终点
研究者
nooshin dalili
Assistant Professor
Shahid Beheshti University of Medical Sciences