Intraoperative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Injury
- Sponsor
- University of Louisville
- Locations
- 1
- Primary Endpoint
- arterial PO2/FiO2 Ratio
- Status
- Withdrawn
- Last Updated
- 2 years ago
Overview
Brief Summary
This study is a prospective observer blinded, central randomization controlled, multi-center clinical trial to assess the relationship between intraoperative FiO2 and postoperative pulmonary complications with lung injury.
Detailed Description
Hyperoxia is common in cardiac surgery and is easy to prevent by adjusting FiO2. Since there is no prospective study on different FiO2 and postoperative pulmonary complications (PPCs) during cardiac surgery. We hypothesized that hyperoxia during cardiac surgery could lead to higher incidence of lung injury and PPCs than normoxia. The objective of this trial is to compare postoperative PPCs and other outcomes between hyperoxia and normoxia strategy by PaO2/FiO2 in CABG patients.
Investigators
Jiapeng Huang
Principal Investigator
University of Louisville
Eligibility Criteria
Inclusion Criteria
- •Age from 18 to 75
- •BMI from 20 to 39.9
- •ASA II/III
- •Undergoing isolated selective on-pump CABG through median sternotomy
- •Subsequent admission to an intensive care unit (ICU).
Exclusion Criteria
- •with severe chronic obstructive pulmonary disease (COPD)
- •Pregnant woman.
- •With current acute coronary syndrome (\<1 week)
- •Severe anemia (hemoglobin \<10g/L)
- •Preoperative supplemental oxygen requirement to maintain arterial O2 of 92%,
- •Right to left shunt in heart
- •Carotid stenosis defined as \>50% stenosis of either carotid artery,
- •Cardiac surgery that requires intraoperative circulatory arrest,
- •Current use of dialysis,
- •One-lung ventilation during surgery,
Outcomes
Primary Outcomes
arterial PO2/FiO2 Ratio
Time Frame: 48hr post operation
minimal postoperative arterial PO2/FiO2 Ratio
Secondary Outcomes
- Pulmonary complications(up to one week while in the hospital)
- length of mechanical ventilation(up to one week while in the hospital)
- length of hospital stay(up to one week while in the hospital)
- length of postoperative ICU stay(up to one week while in the hospital)