Effects of Sorafenib on Intrahepatic Circulations in Patients with Advanced Hepatocullar Carcinoma: A Prospective Cohort Study
Phase 1
- Conditions
- Patients with Advanced Hepatocellular Carcinoma
- Registration Number
- JPRN-UMIN000005410
- Lead Sponsor
- Kitasato University East Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
(1)Patients who have tumor thrombus in main and/or right portal vein; (2) Ongoing pharmacological therapy for portal hypertension with nonselective beta blocker, nitrates and angiotensin II type 1 receptor blocker (ARB); (3) drinking alcohol within 3 months before the start of the study; (4) History of liver transplantation; (5) Pregnancy, and allergy or past adverse reaction to drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changeses of portal venous area before and after administration of sorafenib
- Secondary Outcome Measures
Name Time Method