Study of a Drug [DCVax (tm)-Prostate] to Treat Prostate Cancer When Hormone Therapy is no Longer Effective.
- Conditions
- Prostate Cancer
- Registration Number
- NCT00043212
- Lead Sponsor
- Northwest Biotherapeutics
- Brief Summary
The purpose of this clinical research study is to assess the safety and efficacy of an investigational therapy called DCVax(TM)-Prostate.
- Detailed Description
Patients with hormone refractory prostate cancer are eligible if they have a rising PSA or three or fewer metastatic lesions. The experimental therapy uses a patient's own white blood cells and "teaches" the cells to recognize a "flag" on prostate cancer cells. This may help the immune system destroy prostate cancer cells. Side effects reported from the Phase I/II trial include skin reactions of redness, pain \& swelling at the injection site, and short-lived headache, fever \& fatigue. Full details are available in the informed consent.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Male
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (16)
University of California, Los Angeles
🇺🇸Los Angeles, California, United States
Albany Regional Cancer Center
🇺🇸Albany, New York, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Highlands Oncology Group
🇺🇸Springdale, Arkansas, United States
Cancer Centers of Florida, P.A.
🇺🇸Orlando, Florida, United States
St. Francis Medical Center
🇺🇸Peoria, Illinois, United States
Cancer Care Northwest
🇺🇸Spokane, Washington, United States
Louisiana State University
🇺🇸New Orleans, Louisiana, United States
Clinical Research Solutions
🇺🇸Las Vegas, Nevada, United States
Mary Crowley Medical Research Center
🇺🇸Dallas, Texas, United States
Tyler Cancer Center
🇺🇸Tyler, Texas, United States
Carolinas HealthCare System
🇺🇸Charlotte, North Carolina, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States
University of California, San Diego Medical Center
🇺🇸San Diego, California, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
St. Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States