Thyme Honey for Management of Oral Lichen Planus
Phase 1
- Conditions
- Oral Lichen Planus
- Interventions
- Dietary Supplement: thyme honey
- Registration Number
- NCT06810752
- Lead Sponsor
- British University In Egypt
- Brief Summary
the study aimed to assess the effect of topical application of thyme honey in comparison to 0.1% triamcinolone acetonide oral paste on the relief of pain and clinical improvement in patients with OLP
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
• Patients clinically and histopathologically (if required) diagnosed as suffering from OLP.
- Patients free from any visible oral lesions other than OLP.
- Patients who agreed to take supplied medications.
- Patients who agreed for the biopsy (when required).
Exclusion Criteria
• •Patients suffering from any systemic disease.
- Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
- Treatment with any oral topical medications for at least four weeks prior to the study.
- Pregnant and lactating women.
- In addition, no consideration was given to patients with a history of hypersensitivity to honey.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Thyme Honey group thyme honey Topical application of Thyme Honey Control group Triamcinolone Acetonide Topical application of Triamcinolone acetonide
- Primary Outcome Measures
Name Time Method VAS score assessement 1 month Pain intensity
- Secondary Outcome Measures
Name Time Method measurement of salivary level of miRna155 1 month
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie thyme honey's anti-inflammatory effects in oral lichen planus compared to triamcinolone acetonide?
How does thyme honey compare to corticosteroids in reducing OLP-related pain and mucosal lesions in clinical trials?
Which biomarkers (e.g., IL-17, TGF-β) predict response to thyme honey versus triamcinolone in OLP patients?
What are the safety profiles of thyme honey versus 0.1% triamcinolone oral paste for long-term OLP management?
Are there synergistic effects of combining thyme honey with immunosuppressants or other natural products for OLP treatment?
Trial Locations
- Locations (1)
The British university in Egypt
🇪🇬Cairo, Egypt