Sprint Interval Training: Insulin Sensitivity and Acute-Chronic Metabolic Flexibility in Individuals Living With Obesity: The i-FLEX Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Change in Metabolic Flexibility
研究概览
简要总结
Regular exercise is a cornerstone in the prevention and the management of cardio-metabolic risk factors. Some of the beneficial effect of exercise training occurs through metabolic flexibility' enhancement. Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand, and previous literature has shown that individuals living with obesity have an impaired metabolic flexibility compared to lean individuals. However, there is a lack of empirical evidence on the impact of sprint interval training on metabolic flexibility and whether this translates into clinically meaningful outcomes.
This study will evaluate the impact of 4-week sprint interval training in normal weight individuals as well as individuals living with obesity on acute and chronic metabolic flexibility, irisin secretion and insulin sensitivity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults (Ages 19-60)
- •Physically inactive for individuals living with obesity (not meeting Canadian Physical Activity Guidelines)
- •Normal Weight (BMI ≥ 18.5 < 25.0 km/m2)
- •Obesity (BMI ≥ 30.0 km/m2)
排除标准
- •Individuals with Type 2 Diabetes.
- •Individuals with impaired glucose tolerance.
- •Individuals living with obesity that partake in regular exercise training / meet the Canadian Physical Activity Guidelines.
- •Individuals with a condition or injury that may impact the ability to perform exercise or may be worsened by exercise.
- •Individuals currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism.
- •have experienced >10% weight loss or enrolled in weight loss program within six months of enrolment.
- •require use of medication(s) known to affect insulin sensitivity or secretion within the last 30 days.
- •Medication(s) known to cause weight gain.
- •weight loss medication(s).
结局指标
主要结局
Change in Metabolic Flexibility
时间窗: Baseline and post-intervention (4 weeks)
Chronic and acute metabolic flexibility will be quantified from the respiratory quotient (RQ) at rest and from the respiratory exchange ratio (RER) during a 4-6 minutes steady rate exercise bout.
Change in Insulin Sensitivity
时间窗: Baseline and post-intervention (4 weeks)
Insulin sensitivity will be measure with the Matsuda Index
次要结局
- Change in Irisin(Baseline and post-intervention (4 weeks))
研究者
Martin Senechal
Assistant Professor
University of New Brunswick