Genetic Biomarkers Associated With Child Language Development in Taiwan (II)
- Conditions
- Child Language
- Interventions
- Genetic: The research does not require interventions
- Registration Number
- NCT05510570
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
A study of the relation between genetic biomarkers and child language development in Taiwan.
- Detailed Description
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child language development and language disorder.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 115
- Age 2-18 y/o
- Agree to sign informed consent
Exclusion Criteria of Healthy Child:
- Central nervous system disease
- Neuromuscular Disorders
- Congenital Abnormality
- Genetic Disease
- Dysesthesia
- Hearing Impairment
Inclusion Criteria of Child with language disorder:
- Patients with Language Disorder
- Age 2-18 y/o
- Agree to sign informed consent
Exclusion Criteria of Child with language disorder:
- Hearing Impairment
- Inclusion Criteria of Adult:
- His or her child participated in this study, and gene abnormality was found.
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description experimental The research does not require interventions patients with language disorder
- Primary Outcome Measures
Name Time Method Scores of cognitive function (2 y/o to 6 y/o) baseline Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of language function 2 baseline Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)
Scores of cognitive function 1 baseline Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)
Scores of cognitive function (6 y/o to 16 y/o) baseline Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of cognitive function 3 baseline Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)
Scores of general development baseline Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.)
Applied for children aged 3-71 months. Assessing areas: Cognition, language, motor, social, and self-care skills. Every item is scored 0 or 1, indicating whether the child 'fails' or 'passess' that item.Gene test 1 baseline Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.)
Scores of language function 1 baseline Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)
Gene test 2 baseline Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85, Samtools86, Picard, Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)
- Secondary Outcome Measures
Name Time Method Scores of quality of life baseline Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.)
Scores of participation(2-5 y/o) baseline Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.)
Scores of participation(>6 y/o) baseline Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.)
Scores of activities baseline Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.)
Trial Locations
- Locations (1)
Chang Gung Memoria Hospital
🇨🇳Taoyuan, Taiwan