Comparison of propolis and calcium hydroxide as Intracanal medicament in reducing post instrumentation pain in root canal treatment
- Conditions
- Acute apical periodontitis of pulpal origin,
- Registration Number
- CTRI/2020/12/029532
- Lead Sponsor
- College of dental surgery
- Brief Summary
Pain is significant factor due to which a patient visits a dental practice. Usually, pain of pulpal origin requires endodontic therapy to reduce symptoms.Postoperative pain following root canal instrumentation can be embarrassing for the dentist and annoying for the patient. Irrespective of standard care for endodontic therapy, pain after treatment is a regular event for which there are many causes and bacteria is one of the significant factors. Chemo-mechanical preparation of root canal using sodium hypochlorite irrigation results in 40-60% reduction of bacterial load in root canals, but 60-40% of the canals still remain infected with pathogenic bacteria. However, for efficacious decrease in bacterial load, meticulous instrumentation and intracanal irrigation are needed. It also requires an effective intracanal medicament that reduce bacteria and their byproducts from root canal system and thereby decrease chance of inter appointment pain indirectly. Secondly, in order to eliminate and prevent pain and inflammation directly, an intracanal medicament must have an anti-inflammatory component in it.
Calcium hydroxide [Ca(OH)2] is most commonly used intracanal medicament. Calcium hydroxide has antibacterial effect due to release of hydroxyl ion when it is in aqueous fluid. It has been proved to be ineffective against some of the detrimental endodontic pathogens and lacks anti-inflammatory component.
Propolis, a natural product from bees, is effective against resistant microbes and has anti-inflammatory properties which is cheaper compared to other synthetic medicaments. It consists of flavonoid component that has antibacterial and anti-inflammatory properties. Propolis showed 100% reduction of E. faecalis in 2 days. Antibacterial action for propolis is due to its flavonoid content, various esters of caffeic acid, galangin (3,5,7-trihydroxyflavone), and its bioautogram components. In addition, propolis has the ultraviolet -absorbing component shown to inhibit bacterial DNA- dependent RNA polymerase. Propolis have been used before as intracanal medicament and have shown to be effective. The literature lacks significant studies that investigates the role of Propolis in post instrumentation pain. Henceforth, this study has attempted to evaluate Propolis as intracanal medicament in reducing post instrumentation pain and fill the knowledge gap.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Applicable
- Sex
- All
- Target Recruitment
- 44
- Nepalese patients ≥ 18 years of age  Patient presenting with symptomatic apical periodontitis Tooth with single canal.
- Patient registering pain 4 onward in a Numeric Rating Scale (NRS) scale of 1-10 preoperatively.
- Patient who can understand and provide informed consent.
Patient not willing to participate in the study and communication cannot be accomplished Root canal re-treatment Root canals with an extreme curvature [>30°] Internal or external resorption of root Tooth with open apices Radiographically untraceable canal path.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of propolis and [Ca(OH)2] as intracanal medicament in relieving post instrumentation pain in symptomatic apical periodontitis will be measured 4 hrs, 12 hrs, 24 hrs, 48 hrs and 72 hrs
- Secondary Outcome Measures
Name Time Method •To compare the effect of propolis and calcium hydroxide paste as intracanal medicament in relieving post instrumentation pain at different time intervals. 4 hrs, 12 hrs, 24 hrs, 48 hrs and 72 hrs
Trial Locations
- Locations (1)
College of Dental Surgery,BPKIHS
🇮🇳endodontics,BPKIHSRoom, India
College of Dental Surgery,BPKIHS🇮🇳endodontics,BPKIHSRoom, IndiaNarayan Kumar ChaudharyPrincipal investigator9842350738sanuchaudhary11@gmail.com