Freezing of Gait and the Effects of Vibrotactile Cueing in Parkinson’s Disease - a Cross-Sectional Multimodal Brain Imaging Approach in Virtual Walking Scenarios
Not Applicable
- Conditions
- G20Parkinson disease
- Registration Number
- DRKS00034584
- Lead Sponsor
- niversität Münster, Institut für Sportwissenschaft, Arbeitsbereich Neuromotorik und Training
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
(1) medical diagnosis of idiopathic Parkinson's disease (2) age = 18 years, (3) Montreal Cognitive Assessment (MoCA) of = 18, (4) self-reported daily freezing, (5) normal or corrected-to-normal vision, and (6) a stable medication for 4 weeks prior to inclusion.
Exclusion Criteria
(7) previous history of traumatic brain injuries, (8) inability to stand or walk for at least 30 minutes without walking aids, (9) neuropsychiatric disorders (e.g. depression or anxiety), (10) any medication influencing the nervous system, (11) any severe comorbidities affecting gait, (12) any sensory impairments (e.g. due to polyneuropathy) hampering patients to perceive the vibration of the socks.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is electrocortical activity (EEG), i.e. spatial and temporal changes in different frequency bands. The primary outcome will be compared between Freezing of Gait and normal, unimpaired walking, and between cued vs. non-cued walking.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are fNIRS spatial and temporal Freezing of Gait related changes in hemodynamic activity, i.e. changes in oxygenated and deoxygenated hemoglobin, as well as changes in percentage time frozen and kinematic and kinetic aspects of gait. Secondary outcomes will be compared between FOG and normal unimpaired walking, and between cued vs. non-cued walking.